Blood clots can be life-threatening if left untreated. They have the potential to block essential blood vessels, leading to serious conditions such as stroke, pulmonary embolism, or deep vein thrombosis. Fortunately, there are medications available to prevent and treat these dangerous clots, and one of the most commonly prescribed options is Eliquis.

In this comprehensive article, we will delve into Eliquis (apixaban), exploring its mechanism of action, indications, effectiveness, potential side effects, and important considerations for use. Whether you are a healthcare professional seeking a deeper understanding of the drug or an individual prescribed Eliquis, this article aims to provide a thorough overview of this crucial medication.

Understanding Blood Clots

Before we dive into Eliquis, let’s establish a fundamental understanding of blood clots and their significance in medical contexts.

What Are Blood Clots?

Blood clots are gel-like masses that form when blood thickens and clumps together. They serve an essential purpose in the body, helping to stop bleeding when we get injured. However, problems arise when clots form inside blood vessels when they are not needed. There are two main types of problematic blood clots:

  1. Arterial Clots: These occur in arteries and are often associated with conditions like atherosclerosis, which causes plaque buildup in the arteries. Arterial clots can lead to conditions like heart attacks and strokes.
  2. Venous Clots: These form in veins and are usually associated with conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE). Venous clots can be particularly dangerous as they can break free and travel to the lungs or other vital organs.

Blood clots can be triggered by various factors, including surgery, immobility, hormonal changes, and underlying medical conditions. Effective treatment and prevention strategies are essential in managing these potentially life-threatening conditions.

Eliquis: An Overview

Eliquis, with its active ingredient apixaban, is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for the prevention and treatment of blood clots. It belongs to a class of medications known as direct oral anticoagulants (DOACs), which work by inhibiting specific clotting factors in the blood.

How Eliquis Works

Eliquis operates by targeting a clotting factor called factor Xa. Factor Xa plays a critical role in the blood coagulation cascade, where it helps convert prothrombin into thrombin, a key step in forming blood clots. By inhibiting factor Xa, Eliquis reduces the ability of the blood to clot, thereby preventing the formation of harmful clots.

Indications for Eliquis

Eliquis has several important indications:

  1. Atrial Fibrillation: Eliquis is commonly prescribed to individuals with atrial fibrillation (AFib), a heart rhythm disorder that increases the risk of stroke. By preventing blood clots, Eliquis helps reduce the likelihood of stroke in these patients.
  2. Deep Vein Thrombosis (DVT): Eliquis is used for the treatment and prevention of DVT, a condition in which clots form in deep veins, typically in the legs.
  3. Pulmonary Embolism (PE): Eliquis is also employed for the treatment and prevention of pulmonary embolism, a potentially life-threatening condition where clots travel to the lungs.
  4. Post-Orthopedic Surgery: After certain orthopedic surgeries, such as hip or knee replacement, Eliquis may be prescribed to reduce the risk of DVT and PE.
  5. Reduction of Recurrent Clots: In some cases, Eliquis may be used to prevent the recurrence of blood clots in individuals who have experienced them in the past.

Effectiveness of Eliquis

Eliquis has been the subject of extensive clinical trials, and the evidence supports its efficacy in preventing and treating blood clots. It has been found to be at least as effective as traditional anticoagulants like warfarin, with several advantages, including:

  1. Predictable Dosing: Unlike warfarin, which requires frequent monitoring and dose adjustments, Eliquis has a predictable dosing regimen, making it more convenient for both patients and healthcare providers.
  2. Fewer Drug Interactions: Eliquis has fewer interactions with other drugs and foods compared to warfarin, reducing the risk of complications.
  3. Lower Risk of Bleeding: While anticoagulants inherently increase the risk of bleeding, Eliquis has been associated with a lower risk of major bleeding events compared to warfarin in clinical trials.
  4. No Need for Routine Monitoring: Patients taking Eliquis typically do not require routine blood monitoring, as is necessary with warfarin.

Dosage and Administration

The appropriate dosage of Eliquis can vary depending on the individual’s specific condition, medical history, and other factors. Healthcare providers typically prescribe either 2.5 mg or 5 mg tablets, which are taken orally, usually twice a day.

It is crucial for patients to follow their healthcare provider’s instructions precisely, including the prescribed dosage and any recommendations regarding food or other medications that may interact with Eliquis. Missing doses or taking incorrect amounts can increase the risk of clot formation or bleeding complications.

Potential Side Effects

While Eliquis is generally well-tolerated, like all medications, it can cause side effects. It’s essential for both patients and healthcare providers to be aware of these potential side effects and weigh the benefits of the medication against the risks.

Common side effects of Eliquis may include:

  1. Bleeding: The most significant risk associated with Eliquis is bleeding, which can range from minor bruising to severe bleeding events. Signs of bleeding complications include uncontrolled nosebleeds, unusually heavy menstrual bleeding, blood in urine or stool, or prolonged bleeding from cuts or injuries.
  2. Gastrointestinal Symptoms: Some individuals may experience gastrointestinal discomfort, including nausea, indigestion, or abdominal pain.
  3. Skin Reactions: Rarely, skin reactions like rash or itching may occur.
  4. Liver Enzyme Elevations: In some cases, Eliquis can lead to elevated liver enzymes, which healthcare providers will monitor during treatment.

It’s crucial for patients to report any unusual or severe side effects to their healthcare provider promptly. Additionally, individuals taking Eliquis should take precautions to minimize the risk of bleeding, such as using a soft toothbrush, avoiding activities that carry a high risk of injury, and informing all healthcare providers about their Eliquis use before medical procedures.

Important Considerations for Use

Before initiating Eliquis treatment, both patients and healthcare providers should consider several factors to ensure its safe and effective use:

  1. Medical History: A comprehensive medical history should be discussed with the healthcare provider, including any bleeding disorders, liver or kidney conditions, or other medical conditions.
  2. Other Medications and Supplements: Eliquis can interact with various drugs and supplements, potentially affecting its effectiveness or causing adverse effects. It’s crucial to inform the healthcare provider of all medications and supplements being taken.
  3. Pregnancy and Breastfeeding: The safety of Eliquis during pregnancy and breastfeeding is not well established. Pregnant or breastfeeding individuals should discuss potential risks and benefits with their healthcare provider.
  4. Age and Weight: Eliquis dosages may need adjustment for elderly patients or those with significantly low body weight. Healthcare providers will consider these factors when prescribing the medication.
  5. Monitoring: Regular check-ups and monitoring, including blood tests and assessment of kidney function, may be necessary during Eliquis treatment.
  6. Cost and Insurance: Patients should consider the cost of Eliquis and whether it is covered by their health insurance plan.


Eliquis, with its active ingredient apixaban, plays a vital role in preventing and treating blood clots, which can have life-threatening consequences if left unchecked. Its predictable dosing, fewer drug interactions, and lower risk of bleeding complications compared to traditional anticoagulants make it a valuable tool in modern medicine.

However, it’s essential for both patients and healthcare providers to be vigilant when using Eliquis. This includes close monitoring for signs of bleeding or other adverse effects and careful consideration of potential drug interactions. With appropriate guidance and precautions, Eliquis can help individuals manage and reduce the risk of blood clots, ultimately improving their overall health and quality of life. If you or someone you know has been prescribed Eliquis, consult a healthcare provider for guidance tailored to your specific needs and conditions. Blood clots are a serious medical concern, and the right treatment can make all the difference in preventing complications and ensuring long-term well-being.

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